Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	EPI-AF1	1.34e-08	9.16e-02	8.50e-05	8.07e-03
EPI-AF1	Viral	3.75e-06	3.04e-05	1.52e-02	1.23e-13



Evaluating how well Viral genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI-AF1	0.45	-0.43	-1.11	-0.77	-2.22
EPI-AF1	Viral	0.71	1.53	3.53	1.14	7.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI-AF1	0.01	4.10	0.36	0.22	-0.40
EPI-AF1	Viral	0.01	1.55	4.32	0.80	5.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	FCER;HLA-DRB3;MBL3P;IL-12;Mig;UNC93B;IFNL4;HLA-Cw;SNORA31;HLA;HLA-DRB4;TNFα;SRY
EPI-AF1	119	118	LOC100505841