Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	EPI-AF1	4.79e-03	5.91e-01	3.42e-02	1.54e-01
EPI-AF1 Exclusive	Viral	2.25e-02	5.63e-02	5.04e-01	2.47e-10
Viral Exclusive	EPI-AF1 Exclusive	4.24e-03	6.70e-01	4.78e-02	1.89e-01
EPI-AF1 Exclusive	Viral Exclusive	9.36e-03	3.16e-02	4.55e-01	3.78e-10
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.33e-01
EPI-AF1 Exclusive	Overlap	1.25e-01	1.75e-01	1.05e-01	5.30e-01
Overlap	Exclusives	4.22e-15	2.37e-05	4.26e-24	9.22e-14



Evaluating how well Viral genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF1	0.47	1.18	0.06	0.10	-1.15
EPI-AF1 Exclusive	Viral	0.68	0.93	2.82	0.94	6.96
Viral Exclusive	EPI-AF1 Exclusive	0.47	0.94	-0.05	0.06	-0.87
EPI-AF1 Exclusive	Viral Exclusive	0.69	1.00	2.91	0.82	6.32
Viral Exclusive	Overlap	0.96	0.39	2.17	1.55	1.51
EPI-AF1 Exclusive	Overlap	0.35	-1.50	-1.65	-1.83	-0.63
Overlap	Exclusives	0.67	2.94	5.29	1.39	8.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF1	0.00	2.23	0.58	-0.12	0.00
EPI-AF1 Exclusive	Viral	0.01	0.63	2.77	0.45	5.27
Viral Exclusive	EPI-AF1 Exclusive	0.00	1.71	0.57	-0.04	-0.16
EPI-AF1 Exclusive	Viral Exclusive	0.01	0.52	2.83	0.29	6.14
Viral Exclusive	Overlap	0.00	-0.35	14.78	1.95	2.68
EPI-AF1 Exclusive	Overlap	0.00	-0.56	-1.20	-0.57	-0.19
Overlap	Exclusives	0.02	6.72	4.27	0.71	10.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-DRB4;IL-12;SNORA31;Mig;HLA-Cw;HLA-DRB3;TNFα;UNC93B;SRY;FCER;MBL3P;HLA;IFNL4
EPI-AF1 Exclusive	76	76	
Overlap	1	1