Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	EPI-AF01	9.74e-08	6.81e-01	5.71e-03	8.13e-01
EPI-AF01 Exclusive	Viral	4.96e-03	6.14e-02	5.28e-01	1.74e-09
Viral Exclusive	EPI-AF01 Exclusive	6.21e-08	7.95e-01	1.03e-02	9.60e-01
EPI-AF01 Exclusive	Viral Exclusive	1.06e-01	6.74e-02	8.02e-01	3.06e-09
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
EPI-AF01 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.87e-19	1.33e-19	9.53e-30	1.03e-23



Evaluating how well Viral genes are linked to EPI-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF01	0.51	2.27	0.70	0.84	0.56
EPI-AF01 Exclusive	Viral	0.68	1.22	1.84	0.52	5.66
Viral Exclusive	EPI-AF01 Exclusive	0.51	2.13	0.61	0.61	0.10
EPI-AF01 Exclusive	Viral Exclusive	0.68	0.71	1.76	0.33	6.20
Viral Exclusive	Overlap	1.00	1.90	1.22	1.28	1.73
EPI-AF01 Exclusive	Overlap	1.00	1.52	1.86	1.29	1.62
Overlap	Exclusives	0.67	2.00	9.45	2.25	10.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF01	0.01	4.36	1.33	0.55	0.76
EPI-AF01 Exclusive	Viral	0.01	1.53	3.32	0.56	6.96
Viral Exclusive	EPI-AF01 Exclusive	0.01	3.88	0.93	0.41	-0.04
EPI-AF01 Exclusive	Viral Exclusive	0.01	0.69	2.59	0.09	7.09
Viral Exclusive	Overlap	0.01	41.94	10.27	18.58	34.46
EPI-AF01 Exclusive	Overlap	0.01	4.78	37.32	13.96	31.07
Overlap	Exclusives	0.05	4.13	32.87	4.47	33.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	FCER;MBL3P;SRY;HLA-DRB4;TNFα;IL-12;HLA-Cw;HLA-DRB3;UNC93B;IFNL4;Mig;HLA;SNORA31
EPI-AF01 Exclusive	173	171	C1GALT1C1L;CCDC7
Overlap	1	1