Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	EPI_AF001	3.53e-08	7.74e-01	3.53e-02	1.35e-01
EPI_AF001	Viral	3.22e-02	5.98e-01	2.17e-01	1.15e-04



Evaluating how well Viral genes are linked to EPI_AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI_AF001	0.53	0.81	-0.07	0.30	1.29
EPI_AF001	Viral	0.62	-0.85	-0.95	-0.48	4.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI_AF001	0.01	-0.08	-0.81	-0.32	-0.08
EPI_AF001	Viral	0.01	-0.67	-1.33	-0.62	1.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	SRY;HLA-Cw;HLA-DRB3;Mig;UNC93B;TNFα;MBL3P;IFNL4;IL-12;HLA;HLA-DRB4;FCER;SNORA31
EPI_AF001	136	133	LOC101928841;PPIAL4E;CCDC7