Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	EPI-AF0001	4.27e-14	4.17e-02	3.76e-04	2.05e-01
EPI-AF0001	Viral	2.22e-11	9.68e-09	3.09e-05	4.79e-02



Evaluating how well Viral genes are linked to EPI-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI-AF0001	0.51	-1.90	-1.96	-1.41	0.22
EPI-AF0001	Viral	0.52	-3.03	-6.08	-2.10	0.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EPI-AF0001	0.01	-2.36	-2.01	-1.68	-0.75
EPI-AF0001	Viral	0.01	-1.58	-4.67	-1.29	-0.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	MBL3P;HLA-Cw;HLA;SRY;TNFα;UNC93B;FCER;HLA-DRB4;SNORA31;Mig;IL-12;HLA-DRB3;IFNL4
EPI-AF0001	142	141	JMJD7-PLA2G4B