Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Wave-AF1	1.39e-08	1.72e-04	3.74e-18	3.68e-24
Wave-AF1 Exclusive	Viral	7.47e-04	1.22e-04	6.19e-38	4.58e-24
Viral Exclusive	Wave-AF1 Exclusive	4.41e-09	9.22e-04	2.02e-16	4.56e-22
Wave-AF1 Exclusive	Viral Exclusive	1.37e-03	3.04e-04	6.90e-36	8.67e-23
Viral Exclusive	Overlap	1.69e-04	3.08e-04	1.69e-04	1.95e-04
Wave-AF1 Exclusive	Overlap	2.10e-01	7.93e-01	4.29e-02	8.30e-02
Overlap	Exclusives	8.69e-14	1.25e-24	4.78e-47	1.74e-61



Evaluating how well Viral genes are linked to Wave-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF1	0.75	-2.17	4.06	2.79	12.07
Wave-AF1 Exclusive	Viral	0.81	2.24	6.59	2.66	13.18
Viral Exclusive	Wave-AF1 Exclusive	0.75	-2.82	3.40	2.44	12.13
Wave-AF1 Exclusive	Viral Exclusive	0.81	2.04	6.06	2.77	11.34
Viral Exclusive	Overlap	1.00	2.70	3.16	2.57	3.40
Wave-AF1 Exclusive	Overlap	0.84	1.29	1.41	1.24	2.22
Overlap	Exclusives	0.82	3.96	12.24	2.62	17.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF1	0.03	-0.61	10.36	7.88	36.80
Wave-AF1 Exclusive	Viral	0.03	2.25	6.61	6.34	37.94
Viral Exclusive	Wave-AF1 Exclusive	0.02	-2.65	3.81	3.17	21.35
Wave-AF1 Exclusive	Viral Exclusive	0.03	2.07	6.45	6.03	42.26
Viral Exclusive	Overlap	0.29	334.26	201.85	783.16	579.60
Wave-AF1 Exclusive	Overlap	0.00	3.96	2.16	6.61	4.80
Overlap	Exclusives	0.09	13.01	53.71	11.74	78.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	119	106	HLA;SRY;HLA-DRB4;HLA-Cw;UNC93B;Mig;IFNL4;HLA-DRB3;MBL3P;IL12;FCER;TNFα;SNORA31
Wave-AF1 Exclusive	161	161	
Overlap	4	4