Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Wave-AF01	9.53e-10	1.08e-02	4.56e-14	9.56e-21
Wave-AF01 Exclusive	Viral	2.41e-02	9.10e-04	3.87e-37	8.05e-23
Viral Exclusive	Wave-AF01 Exclusive	3.77e-10	2.49e-02	1.06e-11	7.15e-20
Wave-AF01 Exclusive	Viral Exclusive	2.58e-02	1.32e-03	1.42e-36	1.09e-21
Viral Exclusive	Overlap	1.69e-04	1.02e-02	1.69e-04	2.57e-04
Wave-AF01 Exclusive	Overlap	8.91e-01	8.33e-01	9.21e-03	1.89e-02
Overlap	Exclusives	7.16e-08	4.65e-19	2.02e-44	1.14e-52



Evaluating how well Viral genes are linked to Wave-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF01	0.76	-3.62	2.48	2.28	9.92
Wave-AF01 Exclusive	Viral	0.80	1.63	5.87	2.59	10.59
Viral Exclusive	Wave-AF01 Exclusive	0.75	-4.10	1.84	1.64	10.16
Wave-AF01 Exclusive	Viral Exclusive	0.79	1.40	5.40	2.82	10.51
Viral Exclusive	Overlap	0.99	2.55	2.61	2.78	3.56
Wave-AF01 Exclusive	Overlap	0.86	1.45	1.25	1.38	2.34
Overlap	Exclusives	0.81	1.65	10.63	2.20	14.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF01	0.03	-1.42	7.45	7.70	29.03
Wave-AF01 Exclusive	Viral	0.02	0.65	1.58	2.44	20.57
Viral Exclusive	Wave-AF01 Exclusive	0.02	-3.22	1.94	1.93	14.83
Wave-AF01 Exclusive	Viral Exclusive	0.02	0.27	2.00	2.97	10.51
Viral Exclusive	Overlap	0.29	301.06	157.87	1006.20	198.90
Wave-AF01 Exclusive	Overlap	0.00	-0.22	-0.91	0.94	3.14
Overlap	Exclusives	0.08	5.39	47.92	8.64	48.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	119	106	SNORA31;TNFα;SRY;IL12;HLA-Cw;FCER;Mig;HLA-DRB4;MBL3P;UNC93B;HLA;HLA-DRB3;IFNL4
Wave-AF01 Exclusive	138	138	
Overlap	4	4