Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Wave-AF001	1.00e-09	2.77e-03	6.61e-14	1.28e-22
Wave-AF001 Exclusive	Viral	5.80e-07	3.37e-07	3.67e-45	1.03e-28
Viral Exclusive	Wave-AF001 Exclusive	5.90e-10	1.98e-02	1.20e-12	4.98e-22
Wave-AF001 Exclusive	Viral Exclusive	1.79e-06	1.45e-07	3.90e-45	1.72e-27
Viral Exclusive	Overlap	1.69e-04	1.72e-03	1.69e-04	2.81e-04
Wave-AF001 Exclusive	Overlap	3.44e-01	8.77e-01	2.95e-04	1.79e-03
Overlap	Exclusives	5.37e-18	2.36e-23	5.26e-66	9.13e-58



Evaluating how well Viral genes are linked to Wave-AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF001	0.78	-3.17	3.66	2.41	12.65
Wave-AF001 Exclusive	Viral	0.82	3.11	6.43	2.85	12.26
Viral Exclusive	Wave-AF001 Exclusive	0.77	-3.79	3.08	2.38	10.68
Wave-AF001 Exclusive	Viral Exclusive	0.81	3.13	6.54	3.30	10.11
Viral Exclusive	Overlap	0.99	2.36	2.28	2.29	3.20
Wave-AF001 Exclusive	Overlap	0.94	1.68	0.75	1.64	2.85
Overlap	Exclusives	0.84	2.03	11.68	2.78	20.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave-AF001	0.03	-2.04	8.57	3.29	17.21
Wave-AF001 Exclusive	Viral	0.02	3.71	4.03	4.30	28.64
Viral Exclusive	Wave-AF001 Exclusive	0.02	-2.47	5.13	2.49	17.90
Wave-AF001 Exclusive	Viral Exclusive	0.02	3.55	4.57	5.86	27.81
Viral Exclusive	Overlap	0.03	9.96	20.33	49.37	98.55
Wave-AF001 Exclusive	Overlap	0.00	0.90	-0.36	2.31	0.44
Overlap	Exclusives	0.10	7.91	71.88	13.76	95.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	119	106	HLA-Cw;SRY;MBL3P;Mig;IL12;UNC93B;IFNL4;SNORA31;HLA-DRB3;FCER;HLA-DRB4;TNFα;HLA
Wave-AF001 Exclusive	129	129	
Overlap	4	4