Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Wave_AF0001	7.12e-08	3.39e-04	4.37e-19	1.81e-29
Wave_AF0001 Exclusive	Viral	1.40e-05	2.44e-07	1.05e-46	8.35e-27
Viral Exclusive	Wave_AF0001 Exclusive	5.48e-08	5.42e-04	2.22e-18	1.96e-29
Wave_AF0001 Exclusive	Viral Exclusive	1.39e-05	3.62e-07	1.33e-45	9.79e-27
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Wave_AF0001 Exclusive	Overlap	3.35e-01	4.91e-01	1.05e-01	2.28e-01
Overlap	Exclusives	2.35e-13	1.74e-09	1.03e-43	1.33e-63



Evaluating how well Viral genes are linked to Wave_AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave_AF0001	0.82	-3.17	4.34	2.46	12.20
Wave_AF0001 Exclusive	Viral	0.83	2.94	8.96	3.04	11.55
Viral Exclusive	Wave_AF0001 Exclusive	0.82	-3.34	3.97	2.53	12.61
Wave_AF0001 Exclusive	Viral Exclusive	0.83	3.01	8.30	3.07	11.35
Viral Exclusive	Overlap	1.00	1.97	1.57	1.86	1.92
Wave_AF0001 Exclusive	Overlap	0.84	0.42	0.60	1.34	1.25
Overlap	Exclusives	0.85	1.92	9.63	2.53	17.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Wave_AF0001	0.03	-3.08	6.78	2.14	16.97
Wave_AF0001 Exclusive	Viral	0.03	2.44	2.01	4.69	18.07
Viral Exclusive	Wave_AF0001 Exclusive	0.02	-2.99	5.20	2.38	11.71
Wave_AF0001 Exclusive	Viral Exclusive	0.03	2.02	2.38	5.63	13.10
Viral Exclusive	Overlap	0.02	168.72	10.45	131.82	269.88
Wave_AF0001 Exclusive	Overlap	0.00	0.01	-0.40	0.14	-0.09
Overlap	Exclusives	0.08	3.54	31.82	5.84	76.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-DRB4;IFNL4;SNORA31;MBL3P;FCER;Mig;TNFα;UNC93B;HLA-Cw;HLA;SRY;IL12;HLA-DRB3
Wave_AF0001 Exclusive	122	122	
Overlap	1	1