Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	EAML-AF1	3.15e-06	6.12e-01	9.80e-03	7.78e-01
EAML-AF1 Exclusive	Viral	1.24e-01	2.27e-01	3.11e-02	8.17e-06
Viral Exclusive	EAML-AF1 Exclusive	3.67e-06	7.68e-01	1.80e-02	7.04e-01
EAML-AF1 Exclusive	Viral Exclusive	1.15e-01	2.52e-01	3.88e-02	2.48e-06
Viral Exclusive	Overlap	1.12e-01	2.17e-01	1.12e-01	1.75e-01
EAML-AF1 Exclusive	Overlap	1.66e-01	2.92e-01	2.52e-01	3.06e-01
Overlap	Exclusives	2.39e-03	2.65e-02	3.34e-03	3.51e-04



Evaluating how well Viral genes are linked to EAML-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EAML-AF1	0.49	2.91	1.01	1.07	-0.63
EAML-AF1 Exclusive	Viral	0.66	0.59	0.30	0.02	6.55
Viral Exclusive	EAML-AF1 Exclusive	0.48	3.47	1.02	0.94	-0.71
EAML-AF1 Exclusive	Viral Exclusive	0.66	0.72	0.50	-0.00	5.35
Viral Exclusive	Overlap	0.87	2.46	1.31	1.73	1.36
EAML-AF1 Exclusive	Overlap	0.17	-1.36	-1.05	-0.95	-1.09
Overlap	Exclusives	0.56	0.50	2.89	1.03	4.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EAML-AF1	0.01	4.05	0.95	0.36	-0.56
EAML-AF1 Exclusive	Viral	0.01	0.78	1.93	0.16	5.98
Viral Exclusive	EAML-AF1 Exclusive	0.01	4.12	0.87	0.00	-0.68
EAML-AF1 Exclusive	Viral Exclusive	0.01	1.17	2.05	0.05	3.82
Viral Exclusive	Overlap	0.00	1.53	-0.10	0.66	0.16
EAML-AF1 Exclusive	Overlap	0.00	-0.19	-0.24	-0.44	-0.25
Overlap	Exclusives	0.02	-0.26	1.46	0.24	3.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA;SNORA31;FCER;IL12;SRY;MBL3P;HLA-Cw;IFNL4;UNC93B;Mig;HLA-DRB3;HLA-DRB4;TNFα
EAML-AF1 Exclusive	193	190	CCDC7;LOC101928841;C1GALT1C1L
Overlap	1	1