Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	EAML-AF01	8.89e-10	1.69e-01	1.78e-04	3.86e-01
EAML-AF01	Viral	5.23e-03	2.00e-02	1.50e-01	3.98e-10



Evaluating how well Viral genes are linked to EAML-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EAML-AF01	0.51	3.20	1.57	1.83	0.78
EAML-AF01	Viral	0.70	1.07	2.40	0.78	8.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	EAML-AF01	0.01	4.40	1.99	1.22	0.69
EAML-AF01	Viral	0.02	1.69	5.98	1.25	17.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	IL12;UNC93B;HLA;HLA-DRB3;SRY;IFNL4;SNORA31;HLA-DRB4;HLA-Cw;TNFα;FCER;MBL3P;Mig
EAML-AF01	274	270	LOC101928841;MST1L;CCDC7;C1GALT1C1L