Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	EAML-AF0001	2.47e-19	6.57e-01	2.75e-04	1.29e-01
EAML-AF0001 Exclusive	Viral	9.63e-02	1.84e-01	5.24e-01	4.20e-08
Viral Exclusive	EAML-AF0001 Exclusive	8.34e-19	8.42e-01	5.10e-04	1.31e-01
EAML-AF0001 Exclusive	Viral Exclusive	6.28e-02	1.97e-01	4.71e-01	8.91e-09
Viral Exclusive	Overlap	2.17e-01	6.93e-01	4.91e-01	6.11e-01
EAML-AF0001 Exclusive	Overlap	1.95e-01	1.85e-01	1.66e-01	1.85e-01
Overlap	Exclusives	1.55e-01	2.27e-01	4.87e-03	2.01e-07



Evaluating how well Viral genes are linked to EAML-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EAML-AF0001	0.52	-1.33	-0.83	0.17	1.13
EAML-AF0001 Exclusive	Viral	0.66	-0.18	-1.50	0.04	5.96
Viral Exclusive	EAML-AF0001 Exclusive	0.52	-1.08	-0.65	0.24	0.98
EAML-AF0001 Exclusive	Viral Exclusive	0.67	-0.32	-1.45	0.13	5.33
Viral Exclusive	Overlap	0.34	-0.35	-0.42	-0.40	-0.42
EAML-AF0001 Exclusive	Overlap	0.14	-0.96	-1.22	-1.08	-1.35
Overlap	Exclusives	0.57	1.04	0.59	0.43	4.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EAML-AF0001	0.02	-1.10	-1.08	-0.03	0.12
EAML-AF0001 Exclusive	Viral	0.01	-0.66	-3.15	-0.26	5.82
Viral Exclusive	EAML-AF0001 Exclusive	0.02	-0.98	-0.84	0.11	-0.01
EAML-AF0001 Exclusive	Viral Exclusive	0.01	-0.77	-2.87	-0.29	2.60
Viral Exclusive	Overlap	0.00	-0.32	-0.49	-0.33	-0.32
EAML-AF0001 Exclusive	Overlap	0.00	-0.74	-0.25	-0.15	-0.35
Overlap	Exclusives	0.02	0.25	-1.07	-0.16	2.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-Cw;HLA-DRB3;Mig;FCER;MBL3P;SNORA31;HLA;IFNL4;SRY;HLA-DRB4;TNFα;IL12;UNC93B
EAML-AF0001 Exclusive	282	282	
Overlap	1	1