Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	React_AC5	2.10e-03	1.33e-01	7.53e-02	6.52e-03
React_AC5 Exclusive	Viral	4.89e-02	3.54e-05	2.52e-04	1.58e-13
Viral Exclusive	React_AC5 Exclusive	4.40e-04	1.50e-01	6.79e-02	9.85e-03
React_AC5 Exclusive	Viral Exclusive	4.60e-02	4.38e-05	2.88e-03	1.08e-12
Viral Exclusive	Overlap	1.05e-01	2.17e-01	1.25e-01	1.95e-01
React_AC5 Exclusive	Overlap	1.05e-01	1.18e-01	9.92e-02	1.12e-01
Overlap	Exclusives	1.11e-03	3.55e-08	1.52e-02	7.26e-16



Evaluating how well Viral genes are linked to React_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC5	0.60	1.28	1.47	0.95	2.43
React_AC5 Exclusive	Viral	0.71	1.13	3.12	1.49	7.83
Viral Exclusive	React_AC5 Exclusive	0.60	0.74	1.39	0.73	2.01
React_AC5 Exclusive	Viral Exclusive	0.70	1.06	2.68	1.01	8.05
Viral Exclusive	Overlap	0.87	2.48	1.41	1.67	1.22
React_AC5 Exclusive	Overlap	0.97	1.99	1.65	2.21	1.47
Overlap	Exclusives	0.70	0.65	5.57	1.12	7.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC5	0.00	0.69	0.17	0.13	1.27
React_AC5 Exclusive	Viral	0.01	0.53	2.37	1.52	3.78
Viral Exclusive	React_AC5 Exclusive	0.00	0.57	0.60	0.31	1.01
React_AC5 Exclusive	Viral Exclusive	0.01	0.50	2.19	0.74	6.77
Viral Exclusive	Overlap	0.00	2.25	-0.10	0.41	0.09
React_AC5 Exclusive	Overlap	0.00	0.94	3.95	8.06	0.55
Overlap	Exclusives	0.02	-0.15	6.20	0.53	6.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	TNFα;MBL3P;HLA-DRB3;IFNL4;HLA-DRB4;HLA-Cw;SNORA31;SRY;FCER;Mig;IL12;UNC93B;HLA
React_AC5 Exclusive	46	46	
Overlap	1	1