Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	React_AC2	6.17e-03	3.61e-01	8.63e-02	2.73e-01
React_AC2	Viral	1.02e-01	7.30e-04	8.53e-05	8.07e-14



Evaluating how well Viral genes are linked to React_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	React_AC2	0.59	-0.93	-0.15	-0.08	0.64
React_AC2	Viral	0.72	0.53	3.73	0.74	8.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	React_AC2	0.00	-0.56	-0.39	-0.33	-0.13
React_AC2	Viral	0.01	0.13	1.14	0.23	3.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	IFNL4;FCER;SNORA31;TNFα;SRY;Mig;HLA-DRB4;HLA-DRB3;MBL3P;IL12;HLA;UNC93B;HLA-Cw
React_AC2	6	6