Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	React_AC1	2.40e-02	7.08e-01	5.68e-01	6.56e-01
React_AC1	Viral	2.33e-01	7.30e-03	5.57e-02	8.23e-12



Evaluating how well Viral genes are linked to React_AC1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	React_AC1	0.56	-0.67	-0.32	-0.36	0.73
React_AC1	Viral	0.68	0.90	2.40	0.45	7.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	React_AC1	0.00	-0.47	-0.55	-0.31	-0.11
React_AC1	Viral	0.01	0.35	0.34	-0.05	3.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	FCER;HLA-Cw;HLA-DRB3;UNC93B;HLA;IFNL4;MBL3P;TNFα;IL12;Mig;HLA-DRB4;SRY;SNORA31
React_AC1	9	9