Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	STRING_AC5	9.52e-19	6.66e-02	5.40e-05	2.70e-01
STRING_AC5	Viral	4.07e-01	8.97e-01	1.55e-01	7.21e-06



Evaluating how well Viral genes are linked to STRING_AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC5	0.48	-2.30	-2.16	-0.84	-0.96
STRING_AC5	Viral	0.64	0.37	-0.16	-0.19	4.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC5	0.01	-1.01	-0.76	-0.32	-0.44
STRING_AC5	Viral	0.01	0.02	-1.46	-0.25	5.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA-Cw;UNC93B;SNORA31;MBL3P;TNFα;HLA-DRB3;IFNL4;HLA-DRB4;IL12;FCER;HLA;Mig;SRY
STRING_AC5	143	142	ZNF763