Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	STRING_AC4	6.38e-07	6.57e-01	1.26e-01	9.41e-01
STRING_AC4	Viral	4.79e-05	3.56e-03	3.34e-04	1.82e-03



Evaluating how well Viral genes are linked to STRING_AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC4	0.51	-1.78	-1.21	-0.29	0.24
STRING_AC4	Viral	0.55	-1.10	-3.87	-1.02	2.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC4	0.00	-0.72	-0.96	-0.60	-0.44
STRING_AC4	Viral	0.01	-0.92	-2.83	-0.84	0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA;IFNL4;HLA-DRB3;FCER;MBL3P;SRY;HLA-Cw;SNORA31;UNC93B;TNFα;HLA-DRB4;IL12;Mig
STRING_AC4	55	54	ZNF763