Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	STRING_AC3	2.99e-11	1.55e-01	2.70e-03	2.26e-01
STRING_AC3	Viral	9.99e-07	2.13e-03	3.27e-08	2.08e-02



Evaluating how well Viral genes are linked to STRING_AC3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC3	0.46	-1.53	-2.09	-0.92	-1.38
STRING_AC3	Viral	0.55	-1.34	-3.72	-1.62	1.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC3	0.00	-1.18	-1.53	-1.00	-0.70
STRING_AC3	Viral	0.01	-0.99	-2.98	-0.88	-0.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	SNORA31;TNFα;IFNL4;IL12;SRY;HLA-DRB4;HLA-Cw;HLA-DRB3;FCER;UNC93B;HLA;Mig;MBL3P
STRING_AC3	87	87