Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	STRING_AC2	5.17e-05	7.16e-02	8.34e-03	7.25e-02
STRING_AC2	Viral	4.09e-07	6.11e-02	6.77e-08	8.76e-04



Evaluating how well Viral genes are linked to STRING_AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC2	0.44	0.10	-1.63	-0.67	-1.00
STRING_AC2	Viral	0.59	-0.72	-3.00	-0.69	3.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	STRING_AC2	0.00	0.11	-0.41	-0.49	-0.62
STRING_AC2	Viral	0.01	-0.67	-2.42	-0.55	1.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	123	110	HLA-DRB3;HLA-DRB4;HLA-Cw;IL12;Mig;IFNL4;HLA;SNORA31;MBL3P;TNFα;FCER;UNC93B;SRY
STRING_AC2	21	21