Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EPI-AF1	6.79e-04	2.84e-01	3.14e-02	6.62e-02
EPI-AF1	Covid	1.10e-02	1.39e-01	6.87e-01	1.57e-08



Evaluating how well Covid genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF1	0.46	0.24	-0.39	-0.14	-0.99
EPI-AF1	Covid	0.68	1.14	1.98	0.52	5.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF1	0.00	0.83	0.19	-0.13	-0.17
EPI-AF1	Covid	0.01	0.65	1.10	0.01	3.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	MBL3P;HLA-DRB4;UNC93B;SRY
EPI-AF1	77	77