Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EPI-AF001	8.78e-09	8.85e-01	1.39e-01	2.45e-01
EPI-AF001	Covid	1.16e-01	5.84e-01	2.01e-01	1.15e-03



Evaluating how well Covid genes are linked to EPI-AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF001	0.52	0.69	-0.10	0.21	0.91
EPI-AF001	Covid	0.62	-0.74	-0.91	-0.64	3.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF001	0.01	-0.12	-0.73	-0.29	-0.16
EPI-AF001	Covid	0.01	-0.78	-1.14	-0.77	2.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	SRY;UNC93B;MBL3P;HLA-DRB4
EPI-AF001	136	133	CCDC7;LOC101928841;PPIAL4E