Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EPI-AF0001	3.77e-12	5.03e-02	3.24e-04	2.51e-01
EPI-AF0001	Covid	9.43e-10	4.07e-08	2.62e-06	8.31e-02



Evaluating how well Covid genes are linked to EPI-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF0001	0.50	-1.14	-2.46	-1.42	0.12
EPI-AF0001	Covid	0.51	-2.72	-6.25	-2.39	0.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EPI-AF0001	0.01	-1.70	-2.41	-1.53	-1.01
EPI-AF0001	Covid	0.00	-1.49	-4.17	-1.17	-0.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	MBL3P;HLA-DRB4;SRY;UNC93B
EPI-AF0001	142	141	JMJD7-PLA2G4B