Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	EAML-AF0001	4.50e-06	4.25e-01	4.45e-02	7.42e-01
EAML-AF0001 Exclusive	Covid	1.94e-01	3.96e-01	2.21e-02	3.41e-04
Covid Exclusive	EAML-AF0001 Exclusive	2.50e-06	5.58e-01	5.56e-02	7.62e-01
EAML-AF0001 Exclusive	Covid Exclusive	3.08e-01	3.50e-01	2.61e-02	3.09e-04
Covid Exclusive	Overlap	1.25e-01	3.51e-01	1.49e-01	2.17e-01
EAML-AF0001 Exclusive	Overlap	2.28e-01	3.67e-01	1.66e-01	2.40e-01
Overlap	Exclusives	4.86e-03	6.42e-02	6.99e-03	7.10e-03



Evaluating how well Covid genes are linked to EAML-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	EAML-AF0001	0.49	2.85	1.08	1.02	-0.74
EAML-AF0001 Exclusive	Covid	0.64	0.19	-0.82	-0.41	4.22
Covid Exclusive	EAML-AF0001 Exclusive	0.48	2.58	0.98	1.08	-0.65
EAML-AF0001 Exclusive	Covid Exclusive	0.65	0.09	-0.61	-0.33	4.44
Covid Exclusive	Overlap	0.87	2.14	1.13	1.65	1.17
EAML-AF0001 Exclusive	Overlap	0.17	-1.19	-0.90	-1.16	-1.16
Overlap	Exclusives	0.55	0.60	2.32	0.86	2.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	EAML-AF0001	0.01	3.46	0.47	0.29	-0.68
EAML-AF0001 Exclusive	Covid	0.01	0.36	1.03	-0.13	3.57
Covid Exclusive	EAML-AF0001 Exclusive	0.01	1.71	0.65	0.01	-0.59
EAML-AF0001 Exclusive	Covid Exclusive	0.01	0.28	1.05	-0.12	1.34
Covid Exclusive	Overlap	0.00	0.65	0.01	0.12	-0.08
EAML-AF0001 Exclusive	Overlap	0.00	-0.36	-0.13	-0.41	-0.34
Overlap	Exclusives	0.02	-0.15	1.30	0.10	1.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	UNC93B;MBL3P;SRY;HLA-DRB4
EAML-AF0001 Exclusive	193	190	LOC101928841;C1GALT1C1L;CCDC7
Overlap	1	1