Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EAML-AF0001	3.15e-17	4.40e-01	3.55e-03	1.37e-01
EAML-AF0001	Covid	7.72e-02	1.19e-01	1.81e-01	6.52e-07



Evaluating how well Covid genes are linked to EAML-AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF0001	0.52	-0.89	-0.68	0.12	1.05
EAML-AF0001	Covid	0.67	-0.24	-1.77	-0.43	5.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF0001	0.01	-0.96	-1.08	-0.18	0.05
EAML-AF0001	Covid	0.01	-0.83	-2.56	-0.65	5.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	MBL3P;SRY;UNC93B;HLA-DRB4
EAML-AF0001	283	283