Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EAML-AF01	1.14e-12	7.09e-01	7.06e-04	5.78e-01
EAML-AF01	Covid	1.47e-01	5.98e-01	5.67e-01	1.04e-05



Evaluating how well Covid genes are linked to EAML-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF01	0.50	1.89	0.55	0.91	0.08
EAML-AF01	Covid	0.68	0.32	0.44	0.17	5.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF01	0.01	2.98	0.68	0.78	0.14
EAML-AF01	Covid	0.01	0.67	1.70	0.51	2.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;UNC93B;SRY;MBL3P
EAML-AF01	274	270	CCDC7;MST1L;LOC101928841;C1GALT1C1L