Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	EAML-AF001	9.96e-16	7.25e-01	2.07e-04	4.96e-01
EAML-AF001	Covid	1.59e-01	1.31e-01	1.02e-02	8.45e-06



Evaluating how well Covid genes are linked to EAML-AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF001	0.48	-0.31	-0.75	-0.67	-0.93
EAML-AF001	Covid	0.65	-0.19	-0.98	-0.52	4.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	EAML-AF001	0.01	0.19	-0.47	-0.62	-0.92
EAML-AF001	Covid	0.01	-0.67	-2.18	-0.83	1.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;MBL3P;SRY;UNC93B
EAML-AF001	292	287	HDGFL2;PPIAL4E;CCDC7;LOC101928841;CORO7-PAM16