Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Wave-AF1	4.23e-08	5.63e-04	8.00e-18	8.68e-23
Wave-AF1 Exclusive	Covid	1.61e-05	2.95e-06	4.54e-34	2.26e-23
Covid Exclusive	Wave-AF1 Exclusive	2.90e-08	1.60e-03	2.45e-17	2.19e-22
Wave-AF1 Exclusive	Covid Exclusive	6.31e-06	2.17e-06	2.53e-33	6.17e-23
Covid Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Wave-AF1 Exclusive	Overlap	6.74e-01	3.62e-01	4.04e-02	2.19e-01
Overlap	Exclusives	1.88e-07	1.52e-09	3.00e-22	7.62e-56



Evaluating how well Covid genes are linked to Wave-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave-AF1	0.75	-1.82	4.34	3.38	10.77
Wave-AF1 Exclusive	Covid	0.84	2.51	6.95	2.88	12.06
Covid Exclusive	Wave-AF1 Exclusive	0.75	-1.81	3.19	2.56	10.65
Wave-AF1 Exclusive	Covid Exclusive	0.85	2.40	7.45	3.20	10.77
Covid Exclusive	Overlap	1.00	2.17	2.58	2.42	2.48
Wave-AF1 Exclusive	Overlap	0.73	1.13	0.99	0.86	1.16
Overlap	Exclusives	0.80	1.95	8.09	2.40	17.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave-AF1	0.03	-0.90	8.69	6.56	14.17
Wave-AF1 Exclusive	Covid	0.03	3.36	9.71	4.18	50.92
Covid Exclusive	Wave-AF1 Exclusive	0.02	-1.49	4.41	3.86	13.92
Wave-AF1 Exclusive	Covid Exclusive	0.03	3.36	9.70	7.15	40.67
Covid Exclusive	Overlap	0.16	471.55	184.62	945.25	716.00
Wave-AF1 Exclusive	Overlap	0.00	0.30	-0.38	-0.03	0.10
Overlap	Exclusives	0.06	4.87	26.68	6.70	54.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	84	80	MBL3P;HLA-DRB4;SRY;UNC93B
Wave-AF1 Exclusive	163	163	
Overlap	2	2