Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Wave-AF01	1.82e-09	1.69e-02	5.29e-13	3.51e-19
Wave-AF01 Exclusive	Covid	3.31e-03	3.15e-05	5.47e-36	1.07e-24
Covid Exclusive	Wave-AF01 Exclusive	1.17e-09	4.18e-02	1.64e-11	1.14e-18
Wave-AF01 Exclusive	Covid Exclusive	2.17e-03	9.64e-05	2.24e-36	2.03e-23
Covid Exclusive	Overlap	1.38e-03	1.00e-02	1.38e-03	1.85e-03
Wave-AF01 Exclusive	Overlap	7.33e-01	4.62e-01	6.02e-03	2.58e-02
Overlap	Exclusives	3.92e-07	3.06e-11	9.23e-24	2.23e-46



Evaluating how well Covid genes are linked to Wave-AF01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave-AF01	0.75	-3.40	2.71	2.26	10.72
Wave-AF01 Exclusive	Covid	0.84	2.21	7.22	3.23	10.04
Covid Exclusive	Wave-AF01 Exclusive	0.75	-3.41	2.23	2.18	11.07
Wave-AF01 Exclusive	Covid Exclusive	0.84	2.10	6.23	2.91	10.88
Covid Exclusive	Overlap	0.99	2.69	2.80	2.62	3.30
Wave-AF01 Exclusive	Overlap	0.83	1.25	1.60	1.36	2.06
Overlap	Exclusives	0.80	1.26	6.78	1.87	14.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave-AF01	0.02	-1.49	5.64	5.11	12.75
Wave-AF01 Exclusive	Covid	0.02	0.95	3.86	3.30	9.35
Covid Exclusive	Wave-AF01 Exclusive	0.02	-2.28	2.78	2.80	9.84
Wave-AF01 Exclusive	Covid Exclusive	0.02	0.85	3.92	3.91	8.99
Covid Exclusive	Overlap	0.11	146.66	114.73	173.20	234.37
Wave-AF01 Exclusive	Overlap	0.00	0.33	-0.12	0.39	1.02
Overlap	Exclusives	0.06	5.53	35.00	7.23	50.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	83	79	HLA-DRB4;MBL3P;UNC93B;SRY
Wave-AF01 Exclusive	139	139	
Overlap	3	3