Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Wave_AF001	6.49e-10	6.08e-03	6.61e-14	4.54e-22
Wave_AF001 Exclusive	Covid	6.83e-10	2.12e-09	6.09e-43	1.93e-27
Covid Exclusive	Wave_AF001 Exclusive	5.85e-10	8.42e-03	1.14e-12	3.31e-21
Wave_AF001 Exclusive	Covid Exclusive	8.29e-10	4.38e-09	4.37e-41	1.60e-26
Covid Exclusive	Overlap	1.15e-02	8.35e-02	1.15e-02	1.57e-02
Wave_AF001 Exclusive	Overlap	6.25e-02	4.89e-01	1.22e-02	2.80e-02
Overlap	Exclusives	8.42e-06	6.47e-12	2.69e-42	1.70e-48



Evaluating how well Covid genes are linked to Wave_AF001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave_AF001	0.77	-3.12	3.74	2.25	9.26
Wave_AF001 Exclusive	Covid	0.85	3.56	7.90	3.13	11.02
Covid Exclusive	Wave_AF001 Exclusive	0.77	-3.19	3.87	2.49	10.99
Wave_AF001 Exclusive	Covid Exclusive	0.85	4.14	6.92	3.21	11.33
Covid Exclusive	Overlap	0.99	1.97	1.85	2.65	2.34
Wave_AF001 Exclusive	Overlap	0.90	1.77	0.61	1.52	2.12
Overlap	Exclusives	0.81	0.91	8.97	1.77	15.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Wave_AF001	0.02	-1.92	8.15	4.02	20.33
Wave_AF001 Exclusive	Covid	0.02	5.22	4.62	6.91	25.80
Covid Exclusive	Wave_AF001 Exclusive	0.02	-1.96	8.02	3.33	22.15
Wave_AF001 Exclusive	Covid Exclusive	0.02	4.85	5.17	5.28	29.34
Covid Exclusive	Overlap	0.01	15.65	12.76	28.19	13.21
Wave_AF001 Exclusive	Overlap	0.00	1.09	-0.35	0.60	2.08
Overlap	Exclusives	0.06	3.15	38.92	4.62	52.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	84	80	HLA-DRB4;UNC93B;MBL3P;SRY
Wave_AF001 Exclusive	131	131	
Overlap	2	2