Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	React-AC5	1.19e-02	9.98e-02	1.55e-01	5.44e-03
React-AC5 Exclusive	Covid	1.15e-02	1.08e-05	4.67e-04	1.29e-12
Covid Exclusive	React-AC5 Exclusive	3.55e-03	1.74e-01	1.32e-01	8.58e-03
React-AC5 Exclusive	Covid Exclusive	8.30e-03	3.42e-05	1.59e-03	1.21e-12
Covid Exclusive	Overlap	1.57e-01	3.67e-01	1.05e-01	2.28e-01
React-AC5 Exclusive	Overlap	9.92e-02	1.12e-01	1.05e-01	1.18e-01
Overlap	Exclusives	2.83e-04	1.11e-08	7.33e-03	4.29e-15



Evaluating how well Covid genes are linked to React-AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React-AC5	0.60	1.18	1.77	0.86	2.48
React-AC5 Exclusive	Covid	0.73	1.31	3.62	1.33	6.82
Covid Exclusive	React-AC5 Exclusive	0.60	0.92	1.26	0.88	2.62
React-AC5 Exclusive	Covid Exclusive	0.73	1.20	3.51	1.20	7.40
Covid Exclusive	Overlap	0.87	2.04	1.04	1.93	1.14
React-AC5 Exclusive	Overlap	0.97	1.86	1.87	1.94	1.72
Overlap	Exclusives	0.70	0.93	6.03	1.30	7.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React-AC5	0.00	0.73	0.27	0.34	1.78
React-AC5 Exclusive	Covid	0.01	0.64	2.65	0.79	2.68
Covid Exclusive	React-AC5 Exclusive	0.00	0.52	0.48	0.25	1.54
React-AC5 Exclusive	Covid Exclusive	0.01	0.21	2.58	0.61	5.95
Covid Exclusive	Overlap	0.00	0.72	-0.10	1.75	0.49
React-AC5 Exclusive	Overlap	0.00	5.75	4.76	1.20	0.95
Overlap	Exclusives	0.01	0.01	8.29	0.67	8.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	UNC93B;HLA-DRB4;SRY;MBL3P
React-AC5 Exclusive	46	46	
Overlap	1	1