Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	React-AC4	4.85e-03	8.88e-02	1.12e-03	2.13e-03
React-AC4 Exclusive	Covid	4.57e-07	2.20e-05	1.06e-12	1.44e-15
Covid Exclusive	React-AC4 Exclusive	3.30e-03	2.77e-01	6.33e-03	5.38e-03
React-AC4 Exclusive	Covid Exclusive	1.02e-06	3.04e-05	4.73e-11	4.49e-14
Covid Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
React-AC4 Exclusive	Overlap	1.15e-02	1.73e-02	1.15e-02	1.65e-02
Overlap	Exclusives	2.94e-21	7.12e-19	1.89e-30	1.64e-26



Evaluating how well Covid genes are linked to React-AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React-AC4	0.64	0.65	1.82	1.60	4.52
React-AC4 Exclusive	Covid	0.78	2.00	5.03	2.11	9.01
Covid Exclusive	React-AC4 Exclusive	0.63	0.67	1.32	1.12	3.74
React-AC4 Exclusive	Covid Exclusive	0.78	2.07	5.15	2.34	9.42
Covid Exclusive	Overlap	1.00	1.37	3.29	1.69	2.31
React-AC4 Exclusive	Overlap	0.98	1.78	1.54	1.67	2.25
Overlap	Exclusives	0.76	2.84	7.67	2.21	12.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React-AC4	0.01	3.31	11.51	7.81	14.02
React-AC4 Exclusive	Covid	0.02	2.00	7.90	3.32	21.30
Covid Exclusive	React-AC4 Exclusive	0.01	0.93	3.86	2.61	7.36
React-AC4 Exclusive	Covid Exclusive	0.01	2.08	7.11	3.67	7.40
Covid Exclusive	Overlap	0.07	39.60	577.28	71.60	193.91
React-AC4 Exclusive	Overlap	0.00	4.73	8.15	5.58	2.99
Overlap	Exclusives	0.08	32.45	71.33	9.09	75.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	84	80	SRY;HLA-DRB4;MBL3P;UNC93B
React-AC4 Exclusive	71	71	
Overlap	2	2