Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	STRING-AC5	4.96e-21	9.16e-03	1.10e-05	5.33e-02
STRING-AC5	Covid	7.09e-01	9.31e-01	2.26e-01	7.78e-05



Evaluating how well Covid genes are linked to STRING-AC5 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC5	0.47	-2.62	-3.06	-1.18	-1.37
STRING-AC5	Covid	0.64	0.35	-0.12	-0.36	4.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC5	0.01	-1.19	-1.15	-0.58	-0.55
STRING-AC5	Covid	0.01	0.01	-1.25	-0.44	3.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;MBL3P;SRY;UNC93B
STRING-AC5	143	142	ZNF763