Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	STRING-AC4	7.77e-08	4.51e-01	1.09e-01	7.35e-01
STRING-AC4	Covid	1.49e-03	6.55e-03	1.29e-03	1.76e-03



Evaluating how well Covid genes are linked to STRING-AC4 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC4	0.50	-2.21	-1.65	-0.55	0.08
STRING-AC4	Covid	0.57	-0.86	-3.86	-1.09	1.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC4	0.00	-1.28	-0.93	-0.69	-0.74
STRING-AC4	Covid	0.00	-0.85	-2.54	-0.86	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;HLA-DRB4;SRY;MBL3P
STRING-AC4	55	54	ZNF763