Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	STRING_AC3	1.40e-11	1.21e-01	4.46e-03	1.21e-01
STRING_AC3	Covid	5.44e-08	7.58e-04	7.26e-08	4.32e-02



Evaluating how well Covid genes are linked to STRING_AC3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING_AC3	0.47	-0.99	-2.02	-0.78	-1.06
STRING_AC3	Covid	0.54	-1.84	-3.85	-1.71	1.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING_AC3	0.00	-0.81	-1.19	-0.76	-1.30
STRING_AC3	Covid	0.00	-1.07	-3.05	-1.06	-0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	UNC93B;SRY;HLA-DRB4;MBL3P
STRING_AC3	87	87