Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	STRING-AC2	3.47e-04	2.14e-01	1.31e-01	1.49e-01
STRING-AC2	Covid	4.87e-06	1.93e-01	7.16e-08	5.21e-03



Evaluating how well Covid genes are linked to STRING-AC2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC2	0.49	0.63	-0.68	-0.01	-0.21
STRING-AC2	Covid	0.60	-0.74	-2.36	-0.76	3.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	STRING-AC2	0.00	0.44	-0.33	-0.37	-0.66
STRING-AC2	Covid	0.01	-0.45	-1.71	-0.67	1.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	SRY;UNC93B;HLA-DRB4;MBL3P
STRING-AC2	21	21