Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ATVB Exclusive	GWASCatalog	1.57e-01	4.79e-01	2.59e-02	1.15e-02
GWASCatalog Exclusive	ATVB	5.76e-01	7.90e-01	7.64e-02	7.33e-01
ATVB Exclusive	GWASCatalog Exclusive	2.49e-01	6.59e-01	4.30e-02	1.66e-02
GWASCatalog Exclusive	ATVB Exclusive	9.39e-01	8.27e-01	1.44e-01	4.64e-01
ATVB Exclusive	Overlap	4.55e-02	2.00e-01	3.26e-02	4.74e-01
GWASCatalog Exclusive	Overlap	1.58e-04	1.58e-04	1.69e-04	1.69e-04
Overlap	Exclusives	3.65e-06	1.07e-05	3.52e-18	2.47e-06



Evaluating how well ATVB genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB Exclusive	GWASCatalog	0.57	-0.68	-0.06	-0.76	2.04
GWASCatalog Exclusive	ATVB	0.48	0.58	-0.10	0.10	-0.36
ATVB Exclusive	GWASCatalog Exclusive	0.58	-0.40	0.30	-0.57	2.15
GWASCatalog Exclusive	ATVB Exclusive	0.46	-0.04	-0.69	-0.57	-1.50
ATVB Exclusive	Overlap	0.47	-1.84	-1.26	-1.97	-0.23
GWASCatalog Exclusive	Overlap	1.00	3.66	3.27	3.80	3.53
Overlap	Exclusives	0.62	3.98	4.83	2.86	5.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB Exclusive	GWASCatalog	0.00	-0.91	-0.63	-1.05	0.35
GWASCatalog Exclusive	ATVB	0.02	24.02	35.51	12.23	27.73
ATVB Exclusive	GWASCatalog Exclusive	0.00	-0.71	-0.29	-0.43	0.72
GWASCatalog Exclusive	ATVB Exclusive	0.00	-0.10	-0.55	-0.46	-1.20
ATVB Exclusive	Overlap	0.00	-0.80	-0.72	-0.87	-0.26
GWASCatalog Exclusive	Overlap	0.36	442.24	784.98	1140.38	1013.03
Overlap	Exclusives	0.05	54.80	69.14	44.20	81.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ATVB Exclusive	83	83	
GWASCatalog Exclusive	66	66	
Overlap	4	4