Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	1.26e-01	5.07e-01	2.39e-02	2.00e-02
GWASCatalog Exclusive	ATVB-rare	5.64e-01	7.48e-01	1.11e-01	6.44e-01
ATVB-rare Exclusive	GWASCatalog Exclusive	2.49e-01	6.64e-01	4.60e-02	1.06e-02
GWASCatalog Exclusive	ATVB-rare Exclusive	9.13e-01	8.21e-01	1.95e-01	5.37e-01
ATVB-rare Exclusive	Overlap	6.09e-02	2.04e-01	3.81e-02	5.51e-01
GWASCatalog Exclusive	Overlap	1.58e-04	1.58e-04	1.69e-04	1.69e-04
Overlap	Exclusives	3.43e-06	1.03e-05	2.30e-15	2.98e-06



Evaluating how well ATVB-rare genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	0.57	-0.80	-0.07	-0.92	2.06
GWASCatalog Exclusive	ATVB-rare	0.48	0.61	0.00	-0.02	-0.57
ATVB-rare Exclusive	GWASCatalog Exclusive	0.58	-0.38	0.30	-0.70	2.13
GWASCatalog Exclusive	ATVB-rare Exclusive	0.46	-0.04	-0.70	-0.69	-1.41
ATVB-rare Exclusive	Overlap	0.47	-1.64	-1.22	-1.66	-0.05
GWASCatalog Exclusive	Overlap	1.00	3.90	3.39	3.22	3.38
Overlap	Exclusives	0.62	3.75	5.08	3.02	4.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	0.00	-0.99	-0.69	-1.01	0.04
GWASCatalog Exclusive	ATVB-rare	0.02	20.07	32.81	23.02	24.62
ATVB-rare Exclusive	GWASCatalog Exclusive	0.00	-0.70	-0.34	-0.95	0.43
GWASCatalog Exclusive	ATVB-rare Exclusive	0.00	-0.08	-0.58	-0.51	-0.95
ATVB-rare Exclusive	Overlap	0.00	-0.78	-0.61	-0.90	-0.47
GWASCatalog Exclusive	Overlap	0.36	265.14	758.80	1689.66	1106.63
Overlap	Exclusives	0.05	54.76	70.21	44.34	69.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ATVB-rare Exclusive	83	83	
GWASCatalog Exclusive	66	66	
Overlap	4	4