Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ATVB-rare Exclusive	Nelson	5.45e-01	3.10e-01	7.50e-01	1.54e-04
Nelson Exclusive	ATVB-rare	2.24e-01	5.61e-01	4.97e-03	7.40e-01
ATVB-rare Exclusive	Nelson Exclusive	5.19e-01	3.00e-01	5.79e-01	1.42e-04
Nelson Exclusive	ATVB-rare Exclusive	2.17e-01	6.18e-01	9.37e-03	8.74e-01
ATVB-rare Exclusive	Overlap	3.41e-01	3.85e-01	2.93e-01	8.41e-01
Nelson Exclusive	Overlap	2.50e-03	8.65e-03	1.60e-03	2.95e-03
Overlap	Exclusives	3.42e-06	3.68e-07	4.22e-37	5.86e-10



Evaluating how well ATVB-rare genes are linked to Nelson genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	Nelson	0.57	0.36	1.13	0.29	4.51
Nelson Exclusive	ATVB-rare	0.51	1.36	0.60	0.91	0.32
ATVB-rare Exclusive	Nelson Exclusive	0.57	0.47	1.13	0.16	4.44
Nelson Exclusive	ATVB-rare Exclusive	0.50	0.92	0.20	0.77	0.11
ATVB-rare Exclusive	Overlap	0.47	-1.37	-1.29	-1.39	-0.12
Nelson Exclusive	Overlap	0.97	2.59	2.62	2.46	3.17
Overlap	Exclusives	0.61	2.32	5.47	2.36	8.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	Nelson	0.02	0.18	0.81	0.12	3.82
Nelson Exclusive	ATVB-rare	0.01	6.84	2.89	0.39	1.41
ATVB-rare Exclusive	Nelson Exclusive	0.02	0.25	0.82	-0.02	2.31
Nelson Exclusive	ATVB-rare Exclusive	0.01	2.89	0.65	0.12	0.01
ATVB-rare Exclusive	Overlap	0.00	-0.68	-0.71	-0.60	-0.22
Nelson Exclusive	Overlap	0.03	104.39	73.11	93.56	122.07
Overlap	Exclusives	0.04	4.26	9.04	4.06	11.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ATVB-rare Exclusive	135	135	
Nelson Exclusive	297	290	RPL23AP7;MIR3169;CDKN2BAS;MIR3134;MGC34034;LPAL2;POM121L9P
Overlap	3	3