Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	1.51e-01	1.78e-02	3.41e-01	1.23e-03
GWASCatalog Exclusive	ATVB-rare	5.18e-01	7.93e-01	4.00e-02	9.62e-01
ATVB-rare Exclusive	GWASCatalog Exclusive	1.65e-01	2.64e-02	2.81e-01	8.97e-04
GWASCatalog Exclusive	ATVB-rare Exclusive	5.89e-01	8.35e-01	3.72e-02	9.49e-01
ATVB-rare Exclusive	Overlap	5.78e-01	4.35e-01	7.93e-01	2.06e-01
GWASCatalog Exclusive	Overlap	9.75e-02	9.75e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.20e-04	5.78e-04	7.49e-40	4.82e-06



Evaluating how well ATVB-rare genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	0.63	0.64	1.84	0.87	3.78
GWASCatalog Exclusive	ATVB-rare	0.51	1.59	0.51	0.56	0.45
ATVB-rare Exclusive	GWASCatalog Exclusive	0.63	0.74	1.95	0.90	4.37
GWASCatalog Exclusive	ATVB-rare Exclusive	0.51	1.47	0.52	0.54	0.20
ATVB-rare Exclusive	Overlap	0.87	0.47	0.55	0.43	1.32
GWASCatalog Exclusive	Overlap	1.00	1.27	1.34	1.62	1.89
Overlap	Exclusives	0.61	3.54	5.08	3.35	5.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	GWASCatalog	0.01	1.19	2.49	1.26	1.00
GWASCatalog Exclusive	ATVB-rare	0.01	4.61	1.10	1.18	0.92
ATVB-rare Exclusive	GWASCatalog Exclusive	0.01	1.20	2.69	0.39	4.93
GWASCatalog Exclusive	ATVB-rare Exclusive	0.01	3.12	0.46	0.20	0.16
ATVB-rare Exclusive	Overlap	0.00	-0.20	-0.18	-0.24	0.15
GWASCatalog Exclusive	Overlap	0.04	20.18	118.53	197.80	159.86
Overlap	Exclusives	0.02	9.23	8.66	5.90	8.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ATVB-rare Exclusive	137	137	
GWASCatalog Exclusive	69	69	
Overlap	1	1