Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) MIGen-rare Exclusive GWASCatalog 3.96e-01 1.83e-01 3.87e-01 3.12e-05 GWASCatalog Exclusive MIGen-rare 4.67e-01 3.40e-01 2.37e-02 1.97e-01 MIGen-rare Exclusive GWASCatalog Exclusive 3.60e-01 1.54e-01 4.79e-01 7.00e-05 GWASCatalog Exclusive MIGen-rare Exclusive 4.97e-01 3.14e-01 3.68e-02 1.88e-01 MIGen-rare Exclusive Overlap 5.38e-01 5.35e-01 5.66e-01 2.19e-01 GWASCatalog Exclusive Overlap 1.12e-02 1.12e-02 1.15e-02 1.15e-02 Overlap Exclusives 6.53e-05 8.38e-06 1.13e-24 1.77e-06 Evaluating how well MIGen-rare genes are linked to GWASCatalog genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) MIGen-rare Exclusive GWASCatalog 0.62 0.52 1.18 0.38 3.88 GWASCatalog Exclusive MIGen-rare 0.49 0.86 0.09 0.20 -0.29 MIGen-rare Exclusive GWASCatalog Exclusive 0.62 0.50 1.25 0.43 4.04 GWASCatalog Exclusive MIGen-rare Exclusive 0.49 0.64 -0.24 0.17 -0.60 MIGen-rare Exclusive Overlap 0.82 0.79 0.74 0.38 1.73 GWASCatalog Exclusive Overlap 1.00 2.23 2.08 2.05 2.85 Overlap Exclusives 0.59 3.38 4.41 3.40 4.87 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) MIGen-rare Exclusive GWASCatalog 0.01 0.53 -0.07 0.27 3.72 GWASCatalog Exclusive MIGen-rare 0.01 4.35 4.45 1.70 1.38 MIGen-rare Exclusive GWASCatalog Exclusive 0.00 0.25 -0.16 0.19 2.34 GWASCatalog Exclusive MIGen-rare Exclusive 0.01 1.12 0.69 0.25 -0.00 MIGen-rare Exclusive Overlap 0.00 3.62 4.90 2.54 2.56 GWASCatalog Exclusive Overlap 0.09 80.34 342.54 57.71 310.50 Overlap Exclusives 0.02 16.33 17.83 13.69 18.24 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes MIGen-rare Exclusive 135 134 ZHX1-C8ORF76 GWASCatalog Exclusive 68 68 Overlap 2 2