Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OH Exclusive	GWASCatalog	6.53e-01	8.64e-01	4.46e-01	5.83e-03
GWASCatalog Exclusive	OH	7.53e-01	9.33e-01	8.69e-02	9.08e-01
OH Exclusive	GWASCatalog Exclusive	5.98e-01	8.43e-01	3.33e-01	6.04e-03
GWASCatalog Exclusive	OH Exclusive	4.41e-01	8.37e-01	2.60e-01	6.99e-01
OH Exclusive	Overlap	9.54e-01	9.15e-01	8.04e-01	9.88e-01
GWASCatalog Exclusive	Overlap	1.12e-02	1.12e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.07e-07	4.86e-09	7.21e-07	1.24e-10



Evaluating how well OH genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH Exclusive	GWASCatalog	0.59	-0.60	-0.42	-0.48	2.80
GWASCatalog Exclusive	OH	0.50	0.68	0.34	0.39	-0.09
OH Exclusive	GWASCatalog Exclusive	0.59	-0.66	-0.48	-0.52	3.01
GWASCatalog Exclusive	OH Exclusive	0.48	-0.05	-0.14	-0.16	-0.54
OH Exclusive	Overlap	0.49	-0.05	-0.24	-0.11	-0.05
GWASCatalog Exclusive	Overlap	1.00	3.82	2.80	3.08	2.39
Overlap	Exclusives	0.70	4.42	7.60	3.73	7.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH Exclusive	GWASCatalog	0.00	-0.29	-0.17	-0.30	0.41
GWASCatalog Exclusive	OH	0.03	24.87	47.37	35.59	44.07
OH Exclusive	GWASCatalog Exclusive	0.00	-0.32	-0.18	-0.22	1.37
GWASCatalog Exclusive	OH Exclusive	0.00	-0.13	-0.55	-0.36	-0.76
OH Exclusive	Overlap	0.00	-0.22	-0.15	-0.33	-0.40
GWASCatalog Exclusive	Overlap	0.63	5326.86	2054.23	2940.74	1345.41
Overlap	Exclusives	0.05	41.09	77.36	37.13	76.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OH Exclusive	55	54	C10orf25
GWASCatalog Exclusive	68	68	
Overlap	2	2