Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OH Exclusive	Nelson	5.57e-01	8.98e-01	3.86e-01	5.32e-03
Nelson Exclusive	OH	7.30e-01	9.57e-01	1.08e-01	7.88e-01
OH Exclusive	Nelson Exclusive	6.09e-01	8.83e-01	3.33e-01	8.74e-03
Nelson Exclusive	OH Exclusive	4.72e-01	8.24e-01	2.14e-01	6.45e-01
OH Exclusive	Overlap	9.54e-01	9.10e-01	9.27e-01	9.78e-01
Nelson Exclusive	Overlap	1.12e-02	1.12e-02	1.15e-02	1.15e-02
Overlap	Exclusives	6.99e-08	6.07e-09	8.20e-07	1.65e-10



Evaluating how well OH genes are linked to Nelson genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH Exclusive	Nelson	0.59	-0.68	-0.40	-0.48	2.73
Nelson Exclusive	OH	0.50	0.75	0.43	0.34	-0.10
OH Exclusive	Nelson Exclusive	0.59	-0.66	-0.42	-0.38	2.70
Nelson Exclusive	OH Exclusive	0.48	-0.03	-0.19	-0.07	-0.46
OH Exclusive	Overlap	0.49	-0.02	-0.23	0.05	0.01
Nelson Exclusive	Overlap	1.00	4.18	2.87	3.19	2.36
Overlap	Exclusives	0.70	4.27	7.94	3.51	9.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH Exclusive	Nelson	0.00	-0.35	-0.17	-0.20	1.07
Nelson Exclusive	OH	0.03	17.90	52.49	36.99	35.77
OH Exclusive	Nelson Exclusive	0.00	-0.32	-0.13	-0.10	0.36
Nelson Exclusive	OH Exclusive	0.00	-0.18	-0.51	-0.39	-0.68
OH Exclusive	Overlap	0.00	-0.26	-0.17	-0.24	-0.18
Nelson Exclusive	Overlap	0.63	8250.74	2368.74	2317.85	744.31
Overlap	Exclusives	0.05	38.84	78.69	23.14	27.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OH Exclusive	55	54	C10orf25
Nelson Exclusive	68	68	
Overlap	2	2