Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OH-rare	GWASCatalog	2.57e-01	5.51e-01	2.91e-01	3.76e-03
GWASCatalog	OH-rare	8.62e-01	3.77e-01	6.05e-04	6.69e-01



Evaluating how well OH-rare genes are linked to GWASCatalog genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH-rare	GWASCatalog	0.60	-0.50	-0.45	-0.46	3.43
GWASCatalog	OH-rare	0.51	0.68	0.52	0.43	0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH-rare	GWASCatalog	0.00	-0.41	-0.56	-0.33	1.64
GWASCatalog	OH-rare	0.01	0.14	-0.37	-0.29	-0.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OH-rare	174	173	NT5C1B-RDH14
GWASCatalog	70	70