Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PROCARDIS Exclusive	Nelson	9.33e-01	6.15e-01	2.51e-01	1.84e-04
Nelson Exclusive	PROCARDIS	3.79e-01	3.87e-01	5.27e-02	8.78e-01
PROCARDIS Exclusive	Nelson Exclusive	9.47e-01	6.45e-01	1.86e-01	7.92e-04
Nelson Exclusive	PROCARDIS Exclusive	3.44e-01	3.49e-01	3.25e-02	7.36e-01
PROCARDIS Exclusive	Overlap	5.28e-01	6.56e-01	6.47e-01	7.66e-01
Nelson Exclusive	Overlap	8.99e-01	9.58e-01	7.27e-01	9.54e-01
Overlap	Exclusives	7.97e-02	1.76e-02	2.10e-03	1.77e-10



Evaluating how well PROCARDIS genes are linked to Nelson genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS Exclusive	Nelson	0.56	-0.44	0.04	-0.02	3.51
Nelson Exclusive	PROCARDIS	0.52	0.54	-0.28	0.40	0.32
PROCARDIS Exclusive	Nelson Exclusive	0.56	-0.50	-0.04	-0.16	3.96
Nelson Exclusive	PROCARDIS Exclusive	0.52	0.56	-0.40	0.55	0.52
PROCARDIS Exclusive	Overlap	0.56	0.70	0.23	0.44	0.20
Nelson Exclusive	Overlap	0.48	0.50	-0.02	0.36	-0.11
Overlap	Exclusives	0.61	1.76	3.88	1.34	7.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS Exclusive	Nelson	0.02	-0.05	0.36	0.41	1.91
Nelson Exclusive	PROCARDIS	0.00	0.93	0.13	0.40	0.09
PROCARDIS Exclusive	Nelson Exclusive	0.02	-0.00	0.29	0.16	2.00
Nelson Exclusive	PROCARDIS Exclusive	0.00	1.00	0.13	0.60	0.47
PROCARDIS Exclusive	Overlap	0.00	-0.02	-0.35	-0.17	-0.32
Nelson Exclusive	Overlap	0.00	0.17	-0.30	-0.10	-0.23
Overlap	Exclusives	0.03	1.41	2.77	0.80	6.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PROCARDIS Exclusive	72	72	
Nelson Exclusive	298	291	POM121L9P;LPAL2;MIR3134;RPL23AP7;MIR3169;CDKN2BAS;MGC34034
Overlap	2	2