Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
PROCARDIS-rare Exclusive	Nelson	6.10e-01	5.06e-01	5.83e-01	2.64e-04
Nelson Exclusive	PROCARDIS-rare	2.18e-01	9.44e-01	1.15e-02	3.42e-01
PROCARDIS-rare Exclusive	Nelson Exclusive	6.83e-01	4.60e-01	6.58e-01	3.06e-04
Nelson Exclusive	PROCARDIS-rare Exclusive	1.79e-01	8.83e-01	1.72e-02	6.73e-01
PROCARDIS-rare Exclusive	Overlap	5.95e-01	5.03e-01	7.50e-01	7.05e-01
Nelson Exclusive	Overlap	2.35e-02	6.41e-02	1.45e-02	4.98e-02
Overlap	Exclusives	8.30e-05	2.08e-05	1.74e-15	8.93e-12



Evaluating how well PROCARDIS-rare genes are linked to Nelson genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS-rare Exclusive	Nelson	0.57	-0.36	-0.97	-0.09	4.21
Nelson Exclusive	PROCARDIS-rare	0.53	-0.08	-0.50	0.23	1.31
PROCARDIS-rare Exclusive	Nelson Exclusive	0.57	-0.34	-0.96	-0.13	3.81
Nelson Exclusive	PROCARDIS-rare Exclusive	0.52	-0.38	-0.84	0.00	0.72
PROCARDIS-rare Exclusive	Overlap	0.55	-0.33	-0.45	-0.31	0.40
Nelson Exclusive	Overlap	0.85	2.74	2.01	2.53	2.38
Overlap	Exclusives	0.62	2.30	5.73	2.91	8.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
PROCARDIS-rare Exclusive	Nelson	0.02	-0.78	-1.29	-0.49	2.27
Nelson Exclusive	PROCARDIS-rare	0.01	1.10	-0.03	0.82	1.17
PROCARDIS-rare Exclusive	Nelson Exclusive	0.02	-0.87	-1.47	-0.54	2.34
Nelson Exclusive	PROCARDIS-rare Exclusive	0.01	-0.19	-0.48	0.02	-0.14
PROCARDIS-rare Exclusive	Overlap	0.00	0.44	1.52	0.85	0.24
Nelson Exclusive	Overlap	0.02	174.23	1.67	129.80	50.55
Overlap	Exclusives	0.04	3.34	8.09	4.49	11.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
PROCARDIS-rare Exclusive	193	191	6-Mar;8-Mar
Nelson Exclusive	296	289	POM121L9P;MIR3134;LPAL2;RPL23AP7;CDKN2BAS;MIR3169;MGC34034
Overlap	4	4