Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
rare001_5 Exclusive	Exome	6.88e-01	7.74e-01	4.48e-01	3.12e-01
Exome Exclusive	rare001_5	6.21e-01	6.03e-01	1.24e-01	2.45e-03
rare001_5 Exclusive	Exome Exclusive	8.77e-01	8.05e-01	3.22e-01	1.17e-01
Exome Exclusive	rare001_5 Exclusive	6.83e-01	6.91e-01	1.48e-01	2.11e-03
rare001_5 Exclusive	Overlap	3.35e-01	2.92e-01	5.90e-01	7.73e-01
Exome Exclusive	Overlap	1.85e-01	9.92e-02	4.35e-01	6.52e-01
Overlap	Exclusives	4.55e-01	8.18e-01	3.17e-05	1.01e-02



Evaluating how well rare001_5 genes are linked to Exome genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare001_5 Exclusive	Exome	0.59	-0.45	-0.52	0.01	1.40
Exome Exclusive	rare001_5	0.61	-0.52	0.96	0.34	3.27
rare001_5 Exclusive	Exome Exclusive	0.59	-0.27	-0.36	-0.07	1.62
Exome Exclusive	rare001_5 Exclusive	0.61	-0.48	1.17	0.51	3.73
rare001_5 Exclusive	Overlap	0.57	-0.73	-0.60	-0.57	0.10
Exome Exclusive	Overlap	0.42	-1.41	-2.03	-1.43	-0.28
Overlap	Exclusives	0.58	-0.58	-1.02	-0.42	2.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare001_5 Exclusive	Exome	0.00	-0.40	-0.70	0.22	0.50
Exome Exclusive	rare001_5	0.01	-0.89	0.10	0.07	0.65
rare001_5 Exclusive	Exome Exclusive	0.00	-0.19	-0.46	0.29	0.56
Exome Exclusive	rare001_5 Exclusive	0.01	-0.86	0.53	0.29	2.44
rare001_5 Exclusive	Overlap	0.00	-0.42	-0.47	-0.54	-0.37
Exome Exclusive	Overlap	0.00	-0.32	-0.74	-0.50	-0.34
Overlap	Exclusives	0.01	-0.50	-1.16	-0.60	1.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
rare001_5 Exclusive	72	72	
Exome Exclusive	31	31	
Overlap	1	1