Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
rare01_3 Exclusive	Exome	9.38e-01	8.02e-01	3.43e-01	2.97e-02
Exome Exclusive	rare01_3	2.53e-02	6.48e-01	2.67e-01	1.63e-02
rare01_3 Exclusive	Exome Exclusive	8.63e-01	7.74e-01	4.65e-01	9.13e-02
Exome Exclusive	rare01_3 Exclusive	5.90e-02	6.80e-01	1.51e-01	2.00e-02
rare01_3 Exclusive	Overlap	3.06e-01	6.93e-01	6.93e-01	4.91e-01
Exome Exclusive	Overlap	1.66e-01	1.41e-01	3.51e-01	8.47e-01
Overlap	Exclusives	2.51e-01	4.79e-01	5.39e-12	3.65e-04



Evaluating how well rare01_3 genes are linked to Exome genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare01_3 Exclusive	Exome	0.59	-0.04	-0.16	0.04	2.29
Exome Exclusive	rare01_3	0.56	-1.65	-0.54	-0.80	2.64
rare01_3 Exclusive	Exome Exclusive	0.59	-0.18	-0.18	0.06	1.81
Exome Exclusive	rare01_3 Exclusive	0.56	-1.60	-0.49	-0.74	2.28
rare01_3 Exclusive	Overlap	0.70	-0.53	0.26	0.02	0.63
Exome Exclusive	Overlap	0.42	-1.25	-1.73	-1.40	-0.13
Overlap	Exclusives	0.58	-0.18	-1.16	0.11	3.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
rare01_3 Exclusive	Exome	0.00	-0.70	-1.08	-0.60	-0.06
Exome Exclusive	rare01_3	0.01	-1.31	-0.82	-0.52	0.20
rare01_3 Exclusive	Exome Exclusive	0.00	-0.89	-1.05	-0.72	-0.02
Exome Exclusive	rare01_3 Exclusive	0.01	-1.17	-0.77	-0.68	0.65
rare01_3 Exclusive	Overlap	0.00	-0.59	-0.18	-0.39	-0.16
Exome Exclusive	Overlap	0.00	-0.33	-0.72	-0.39	-0.20
Overlap	Exclusives	0.01	-0.25	-1.08	-0.17	2.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
rare01_3 Exclusive	121	121	
Exome Exclusive	31	31	
Overlap	1	1