Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ATVB-rare Exclusive	ClinVar	1.62e-01	3.00e-02	2.24e-01	7.96e-06
ClinVar Exclusive	ATVB-rare	1.58e-01	5.58e-01	2.94e-02	8.43e-01
ATVB-rare Exclusive	ClinVar Exclusive	1.99e-01	3.77e-02	2.24e-01	8.89e-06
ClinVar Exclusive	ATVB-rare Exclusive	1.45e-01	6.06e-01	3.38e-02	7.83e-01
ATVB-rare Exclusive	Overlap	6.90e-01	3.80e-01	8.29e-01	2.17e-01
ClinVar Exclusive	Overlap	9.75e-02	9.75e-02	9.92e-02	1.12e-01
Overlap	Exclusives	4.08e-02	6.21e-03	5.11e-34	5.36e-04



Evaluating how well ATVB-rare genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	ClinVar	0.72	0.81	2.50	0.77	4.66
ClinVar Exclusive	ATVB-rare	0.51	0.82	0.68	0.63	0.44
ATVB-rare Exclusive	ClinVar Exclusive	0.71	0.77	2.52	0.77	4.78
ClinVar Exclusive	ATVB-rare Exclusive	0.51	0.85	0.57	0.46	0.52
ATVB-rare Exclusive	Overlap	0.87	0.39	0.64	0.32	1.34
ClinVar Exclusive	Overlap	1.00	1.29	1.35	1.51	1.59
Overlap	Exclusives	0.59	1.19	3.28	2.17	4.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ATVB-rare Exclusive	ClinVar	0.00	0.04	1.70	-0.02	2.96
ClinVar Exclusive	ATVB-rare	0.01	1.28	0.40	0.21	0.42
ATVB-rare Exclusive	ClinVar Exclusive	0.00	-0.05	1.32	0.19	3.20
ClinVar Exclusive	ATVB-rare Exclusive	0.01	1.12	0.20	0.23	0.22
ATVB-rare Exclusive	Overlap	0.00	-0.25	-0.11	-0.30	-0.10
ClinVar Exclusive	Overlap	0.01	2.94	11.44	21.46	5.05
Overlap	Exclusives	0.02	6.22	8.11	4.11	6.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ATVB-rare Exclusive	137	137	
ClinVar Exclusive	38	38	
Overlap	1	1