Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MIGen-rare Exclusive	ClinVar	9.40e-06	1.05e-07	2.35e-04	8.08e-11
ClinVar Exclusive	MIGen-rare	2.52e-01	4.44e-01	6.53e-03	7.02e-01
MIGen-rare Exclusive	ClinVar Exclusive	2.77e-05	6.49e-08	1.51e-04	1.30e-10
ClinVar Exclusive	MIGen-rare Exclusive	3.31e-01	3.53e-01	1.27e-02	6.74e-01
MIGen-rare Exclusive	Overlap	9.75e-02	9.75e-02	9.92e-02	1.25e-01
ClinVar Exclusive	Overlap	9.75e-02	9.75e-02	9.92e-02	1.12e-01
Overlap	Exclusives	2.96e-02	3.15e-05	1.51e-21	9.40e-06



Evaluating how well MIGen-rare genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MIGen-rare Exclusive	ClinVar	0.80	2.60	5.60	2.44	6.20
ClinVar Exclusive	MIGen-rare	0.51	2.43	0.98	1.06	0.29
MIGen-rare Exclusive	ClinVar Exclusive	0.80	2.51	5.58	2.46	6.27
ClinVar Exclusive	MIGen-rare Exclusive	0.50	2.28	1.05	0.87	0.29
MIGen-rare Exclusive	Overlap	0.99	1.61	1.80	1.06	1.66
ClinVar Exclusive	Overlap	1.00	1.28	1.33	1.58	1.54
Overlap	Exclusives	0.57	0.60	2.94	2.20	3.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MIGen-rare Exclusive	ClinVar	0.01	2.76	3.85	2.55	8.49
ClinVar Exclusive	MIGen-rare	0.01	1.27	3.10	2.57	1.33
MIGen-rare Exclusive	ClinVar Exclusive	0.01	2.13	3.63	1.91	6.61
ClinVar Exclusive	MIGen-rare Exclusive	0.01	0.98	2.50	1.02	2.15
MIGen-rare Exclusive	Overlap	0.00	9.33	5.34	4.28	2.46
ClinVar Exclusive	Overlap	0.01	3.22	11.55	10.76	1.90
Overlap	Exclusives	0.02	7.09	14.09	6.64	12.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MIGen-rare Exclusive	136	135	ZHX1-C8ORF76
ClinVar Exclusive	38	38	
Overlap	1	1