Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
OH-rare	ClinVar	8.12e-01	9.21e-02	8.17e-01	8.35e-06
ClinVar	OH-rare	7.17e-01	1.03e-01	7.05e-04	1.38e-01



Evaluating how well OH-rare genes are linked to ClinVar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH-rare	ClinVar	0.72	0.63	2.81	0.54	5.06
ClinVar	OH-rare	0.54	3.32	2.00	1.95	1.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
OH-rare	ClinVar	0.00	-0.01	3.05	-0.06	2.71
ClinVar	OH-rare	0.01	2.50	0.82	1.00	0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
OH-rare	174	173	NT5C1B-RDH14
ClinVar	39	39